Wellbutrin (Bupropion Hcl)

Wellbutrin Review

Wellbutrin SR (Anti Depressant) is a pharmaceutical prescription antidepressant, which acts directly on the brain and other nerve cells. It is also used to treat ADHD (Attention Deficit Disorder), bipolar depression, chronic fatigue syndrome, cocaine addiction, nicotine addiction, and lower back pain. Also, aids in quitting smoking (identical to Zyban). It is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.
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Wellbutrin Drug Class and Mechanism

Wellbutrin Uses

Placebo-controlled double-blind clinical studies have confirmed the efficacy of bupropion for clinical depressionComparative clinical studies demonstrated the equivalency of bupropion and sertraline (Zoloft), fluoxetine (Prozac), paroxetine (Paxil) and escitalopram (Lexapro) as antidepressants. A significantly higher remission rate with bupropion treatment than for venlafaxine (Effexor) was observed in a recent study.Unlike all other antidepressants, except mirtazapine (Remeron) and maprotiline (Ludiomil), bupropion does not cause sexual dysfunction and the occurrence of sexual side effects is not different from placebo. Bupropion treatment is not associated with weight gain; on the contrary, at the end of every study comparing bupropion with placebo or other antidepressants the bupropion group had a lower average weight.Bupropion is more effective than SSRIs at improving symptoms of hypersomnia and fatigue in depressed patients.Bupropion reduces the severity of nicotine cravings and withdrawal symptoms. After a seven-week treatment, 27% of subjects who received bupropion reported that an urge to smoke was a problem, versus 56% of those who received placebo. In the same study, 21% of the bupropion group reported mood swings, versus 32% of the placebo group.Bupropion slows the weight gain that often occurs in the first weeks after quitting smoking (after seven weeks, the placebo group had an average 2.7 kg increase in weight, versus 1.5 kg for the bupropion group). With time, however, this effect becomes negligible (after 26 weeks, both groups recorded an average 4.8 kg weight gain).

Wellbutrin Side Effects

This medication is generally well tolerated. Dry mouth, headache, increased sweating, nausea/vomiting, constipation, anxiety, fatigue and blurred vision may occur. If these effects persist or worsen, notify your doctor. Report promptly: unusual weight loss or gain, palpitations, agitation, trouble sleeping. Unlikely but report promptly: tremor, dizziness, fainting, mood changes, slowed movements, difficulty urinating, decreased sex drive, and drowsiness. Very unlikely but report promptly: seizures, mental problems, fever, muscle aches, yellowing of the eyes or skin. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms may include trouble breathing, rash, itching, swelling, or severe dizziness. If you notice other effects not listed above, contact your doctor or pharmacist.

Wellbutrin Pregnancy

Wellbutrin Overdose

Overdose of bupropion results in significant clinical effects in over one-third of cases.[69] The most common symptoms include sinus tachycardia, hypertension, drowsiness, lethargy, agitation, nausea and vomiting, and in particular delirium and seizures. Less commonly additional symptoms include auditory and visual hallucinations, coma,and ECG changes such as conduction disturbance or arrhythmia.

In the majority of childhood exploratory ingestions involving one or two tablets, children will remain asymptomatic. In teenagers and adults seizures are more commonly observed with the seizure rate increasing tenfold with doses of 600 mg daily. One overdose study suggested a dose-dependent relationship with seizures; patients ingesting more than 4.5 g were likely to have a seizure and nearly all patients ingesting more than 9 g had a seizure.

There is no specific antidote for bupropion; treatment is supportive, and focuses on maintaining airway patency and controlling seizures with high dose intravenous benzodiazepines or barbiturates if seizures are refractory to benzodiazepines. Gastric decontamination may be of little benefit given the risk of seizures and aspirationbut activated charcoal is recommended,[69] additionally whole bowel irrigation should be undertaken in those ingesting sustained release formulations.] Toxic effects may be delayed in onset, with seizures developing as late as 32 hours, subsequently patients should undergo electroencephalographic monitoring for 48 hours.

Bupropion overdose rarely results in death, although cases have been reported.] Fatalities are typically associated with large overdosage and related to metabolic acidosis and hypoxia as complications of status epilepticus with associated cardiorespiratory arrest.There is one published case report of successful treatment of refractory cardiac arrest in overdose of bupropion and lamotrigine using lipid rescue.

Wellbutrin More Information

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Too much of this medicine can increase the risk of a seizure. Limit the consumption of caffeine while taking Wellbutrin SR.